My neurologist has just changed me from Tecfidera to a new drug, Mayzent. Have family history with addictions. Clin Neurol Neurosurg. I was sprung out of my head as I barely drink soda (i'm a 4-6 oz as needed for a pick me up) so it was a lot for me. Sometimes We forget to tell them everything, or they're not listening, perhaps because we are not clear enough, or insistent enough or just plain don't make ourselves clear. Someone along the way had also said that sometimes it may increase libido in women???? I was given Modafinil (generic for Provogil). But you can’t live like that so neuro started me on amantadine and I’ve had some of the worst headaches daily. Press question mark to learn the rest of the keyboard shortcuts. When I did go to work, no one noticed how different I was or how much I was struggling. I'm hoping to figure out if i need it or not. Methods I did! I started forgetting to take the afternoon dose because I had so much energy that I didn’t need it, and I told my MD that. Amantadine is an antiviral medication used to prevent or treat certain influenza infections; it is also given as an adjunct for the treatment of Parkinson's disease. For one of the most prevalent symptoms of MS, fatigue, methylphenidate, modafinil, and amantadine are commonly prescribed. I have had the same irritability effect on any CNS fatigue drug like modafinal, Adderall, ampyra. Dopamine affects a structures in the brain collectively known as the basal ganglia, which help regulate movement, emotional response, and the ability to experience pleasure and pain. Amantadine is a treatment for Parkinson’s disease that can also be used to treat fatigue in patients with multiple sclerosis (MS). My fatigue has gotten butter but my new normal had me passing out at 9 not able to help put the kids to bed and feeling like 8/9 hours asleep was never enough. I am have never been on Amandatine so I am really not very much help to you with this question. My doctor recently prescribed amantadine for my MS fatigue. My neuro said it was an energy pill (not) but it does help me focus. For years and years I've been taking Amantadine for many years (~15 or more). Amantadine, sold under the brand name Gocovri among others, is a medication used to treat dyskinesia associated with parkinsonism and influenza caused by type A influenzavirus, though its use for the latter is no longer recommended due to drug resistance. I'm not trying to get a high off it. Nourbakhsh B, et al. There is one feature article on amantadine alone, ... Facebook Twitter Reddit Pinterest Tumblr WhatsApp Email Link. The aim of our study was to compare efficacy of amantadine, modafinil and ALCAR with placebo in patients with MS. But you can’t live like that so neuro started me on amantadine and I’ve had some of the worst headaches daily. Substantial evidence supporting their efficacy is however lacking. Multiple sclerosis (MS) is a common neurological disorder with a variety of manifestations including fatigue. I find that I was 'tired' cause my life was 'tiring' which is why small MS signs were missed until the major relapse that led to the diagnosis. Waiting...waiting...more headaches . I probably wouldn’t have failed any real tests either. The efficacy of amantadine in reducing fatigue in people with MS is poorly documented, as well as its tolerability. No need for the apology, I get it! It has been demonstrated that this medication, through some unknown mechanism, is sometimes effective in relieving fatigue in multiple sclerosis. Amantadine Canada. How do you like Provigil? Mean fatigue during the washout period was lower than during the placebo run-in period, independently of which treatment had been given first. This turned into a lack of focus and more fatigue and experimentation with some caffeine tablets (I barely drink soda/no coffee). I still have my caffeine in the morning, but it’s less than it use to be, and a that’s work in progress. Not alot on the internet about amantadine for fatigue. Background Methylphenidate, modafinil, and amantadine are commonly prescribed medications for alleviating fatigue in multiple sclerosis; however, the … Columnist Laura Kolaczkowski is caught up in a situation in which her insurance provider wants to switch MS fatigue medication from modafinil to amantadine. I am now the proud owner of a box of Amantadine. The results of this study do not support an indiscriminate use of amantadine, modafinil, or methylphenidate for the treatment of fatigue … It acts as a nicotinic antagonist and noncompetitive NMDA antagonist. Looks like you're using new Reddit on an old browser. For fatigue, one of the most prevalent subjective symptoms in MS patients, methylphenidate, modafinil, and amantadine are commonly prescribed. I do not find my fatigue any worse and it seems as if my muscle spasticity is getting a little bit better with each infusion. The first day was like she was on speed. Same thing with full dose. Conversations about support, research, drug therapies, nutrition, exercise, and more. Side effects can include a dry mouth, constipation, nausea, anxiety and hyperactivity. For Fatigue: “Two weeks ago, I began Amantadine for extreme fatigue from MS. I was hoping that the amantadine would help with the fatigue and give me some focus. Mostly just 1/2 pill but full pill if fatigue worsens, It's the only one I've tried and it works for me, Fall asleep on couch @ 9p up again at 10, asleep 11 awake 430a, I also take amantadine, my dr said 1 when awakening( I get up at 7am) and 1 at noon.I didn't have headaches and it works for me but a side effect is itching, he cut me back to one a day,which took away the itching but I do feel more fatigue again. I hope you find a dose that works for you! I haven't gotten a response yet..but seriously... i'm not sure if this is helping if i'm doing OK without it just crashing out by 9... it's not a bad thing to crash by 9.. i just can't stay focused the next day cause I just feel warn/fatigued. Summary. Your imitations may be much more severe than mine, so we really can't compare, but if possible, talk to your doctor and ask about switching to Provigil or one of its generics. I’m glad that I found something to give me my life back, and that’s my hope for you. Modafinil was the one I was taking - I call it "the Poor Man's" Provigil. I am taking both provigil, 200mg, 2 per day and 1 amantadine, 100mg and fatigue is still an issue. So she can go off of it for a couple weeks, the hop back on to get the effects back. Objective: Fatigue affects more than 60% of multiple sclerosis (MS) patients and is one of the most troublesome symptoms of the disease. I went from being too exhausted to do anything beyond keep my 4 month old baby clean, fed and safe, to being able to think in the morning, do laundry if I started it early enough and shop/cook a few meals per week. I did that twice and that just made sleep wise but my focus amazing! In this study, the effect of ondansetron and amantadine in the treatment of fatigue was compared. Forums. All in all, these agents should not be used indiscriminately for the treatment of MS-related fatigue. My MD told me to take the second dose by noon. Can't find much info on the net about it. I'm a little wary of anything that could be addictive. I do better with more sleep. Substantial evidence supporting their efficacy is lacking, however. I had both motivation and focus on provigil. I continued treatment and have noticed a marked improvement of cognitive functioning, ability to maintain focus and recall events with more ease. She still feels tired, but not so tired that she can't do anything. Was on Amantadine for 6 months prior to Provigil. Hope it get's better for you. I found I have to take the 2nd dose by 3pm or I can’t sleep. Discontinuation of naproxen leads to resolution of signs and symptoms. Seems like docs have to try Amantadine first before they can prescribe, and get insurance approval, for Provigil. At last someone who does not think that it cant be a problem as I am retired! Amantadine produced a small but statistically significant decrease in fatigue. It was humorous in an alarming kind of way. After that she settled down. Enjoy the little one - they truly do grow up TOO FAST. My wife has been on Amantadine for a couple of months now. Has anyone had that happen? I’m hopeful as things keep changing and I’m further in my Ocrevus dosing it’ll keep getting better as everyone on the forum predominantly tend to have good reactions the longer they are on it. 1,2 This condition has been reported worldwide, and case definitions have been developed by the Centers for Disease Control and Prevention. I just want to sleep, FOCUS when I’m awake and feel good in those waking hours. YMMV. Have not seen 9PM for months and that is with naps during the day. If it was a really good day, we could walk around the lake. It’s hard to explain simply wanting to be engaged with your own life to someone who has never had that taken from them long term. Our goal was to compare the efficacy of these three medications with each other and placebo in patients with multiple sclerosis fatigue. If you take amantadine within a few hour of going to bed it could lead to difficulty sleeping or vivid dreams. Thanks! It did help for a while but it didn’t do what I needed it to, even with caffeine. Under these circumstances, as fatigue develops, intracortical inhibitory circuits located within or upstream to M1 might be engaged in an opposite manner. I do know what you mean. … Methylphenidate, modafinil, and amantadine are commonly prescribed medications for alleviating fatigue in multiple sclerosis; however, the evidence supporting their efficacy is sparse and conflicting. Thanks KDali. Any help would be appreciated. Hello, anyone else in a similar situation. I just want to be able to wake up, feel energized enough to do daily tasks, play with my kids and get maybe 1 PROJECT off my to do list and I would think that's a win! Amantadine has an average rating of 9.4 out of 10 from a total of 5 ratings for the treatment of Chronic Fatigue Syndrome. Having kids, work and personal obligations changes how much time you can devote to everything. 200mg at breakfast and another 100 at lunch. Jul 19, 2014 #2. So I’m waiting for them to advise. Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked. So talk to your doctor and assert yourself. I take it in the morning but can easily nap/sleep. Evaluating the effects of amantadine, modafinil and acetyl-L-carnitine on fatigue in multiple sclerosis – result of a pilot randomized, blind study. Jul 19, 2014. I found out today my insurance doesn't find value in occupational therapy - who else is going to give me tips on energy conservation, effective exercises for MS and more? Amantadine acts directly on the central nervous system and helps stimulate the production of dopamine, a neurotransmitting chemical similar to adrenaline. I still have nothing to help with that at all. I myself took this drug had headache but no help with fatigue. Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them. That’s why I asked about reducing the dose to once a day but no reply yet. The doc said people can become used to the drug, and that cycling it can help. Patients dont need any more services beyond a daily dose of one of these drugs. I had weird foot pain in the morning and thought it was baby weight, so I did the keto diet to lose 10lbs and help me get back to light jogging. I do not feel as if it works nearly as well as Modafinil, but I have to remember, it's only been 2 weeks. I have only been on Amantadine for about 2 weeks. No words. For the most part I am doing well (80% of the time).. i just want to keep scratching things off the list and know that when I wake up i'll do more than just feel like falling asleep. 2013 ;115(Suppl 1): S86 – 89 . I started Ocrevus at the end of May 1st ½ injection and 2ns early June. It didn't work for me which is a shame because it was much less expensive than Provigil. We have enough other issues to deal with then to bring our heads functioning at very low norm with a migraine.. In the randomized crossover TRIUMPHANT-MS trial, none of the 3 agents was superior to placebo in improving MS-related fatigue, but they did cause more adverse events. he explained that the Mayzent reacts adversely with the Modafini I am taking for improved energy. The effects of amantadine from one randomised, double-blind, placebo-controlled, cross-over trial comparing amantadine with placebo for the treatment of fatigue in 80 people with Guillain-Barré syndrome (GBS) were uncertain for the proportion of people achieving a favourable outcome six weeks post-intervention (odds ratio (OR) 0.56 (95% confidence interval (CI) 0.22 to 1.35, N = 74, P = 0.16). Randomized, placebo-controlled, crossover, 4-sequence, 4-period, double-blind (participants and investigators), multicenter trial of 3 commonly used medications for treatment of MS-related fatigue (amantadine, modafinil, methylphenidate) versus placebo in fatigued subjects with MS defined by McDonald Criteria. I know I have been forcing myself to do more, and a million times a day I feel I HAVE to sit down. In in my month of crappy and hoping that it ends soon. I just find there are days where focusing for 5 or having the energy for 5 can be a challenge. I wrote my neuro asking if i should just take it 1x a day instead of twice. This turned into a lack of focus and more fatigue and experimentation with some caffeine tablets (I barely drink soda/no coffee). I've heard of others that have good luck with Ritalin. As many of us have mentioned, myself included, 90 days is the min for results but a year+ is better. That's where i'm flustered. Sorry mini rant. I don't sit down tho, I keep going. ☀️. That sounds horrible. Amantadine is generally well tolerated with mild side effects. So I have had the strangest symptom, probably for around a year now, possibly more. I tried amantadine and provigil. Amantadine Therapy for Fatigue in Multiple Sclerosis T.J. Murray ABSTRACT: We carried out a double blind control study of fatigue in 32 patients with multiple sclerosis, comparing amantadine hydrochloride 100 mg twice a day and placebo. I just not into severe headaches. Here’s to hoping to find that right mix!! Just had my second full dose of Ocrevus. I think if i just had some basic work, personal projects like the groceries and taking care of the kids - id be good. Anyone else out there dealing with this? Fatigue may be an incapacitating feature of this illness.Amantadine has been found to be beneficial in the fatigue of multiple sclerosis.1,2 The basis for this is uncertain. I’ve been taking modafinil for a few years now, and have even recently moved up to the maximum dose of 400mg a day (200mg morning and early afternoon). Thanks! Here's to another good day for you and all the perks of 6th month crazy infusions! Fighting fatigue!Modafinil vs amantadine Hello all, like a lot of us one of my biggest struggles is with fatigue. Many generic formulations of amantadine are available. So sorry your going thru this, I was on it and stopped, it didn't help me. Wondering if anyone has experience with this drug? 100% of those users who reviewed Amantadine reported a positive effect, while 0% reported a negative effect. I did that twice and that just made sleep wise but my focus amazing! Anything that would give me migraine type headaches I would certainly talk to my doctor about and probably asked if I could get a different medicine or get off of it totally. JMWCO, it's Fancy1959. What did you end up doing if it didn’t work? I think it would be easier if i had less obligations (working on it) and could just sit and say I can FOCUS on this for the next 60 minutes and take a break. In this case it is building up the tolerance to the drug and have been asked to keep it up for another few weeks but reduce the dosage to help with the sleep issues. Very depressing, it was like after having her, my fatigue and cog fog was on fast forward. Notably, amantadine restored these adapting changes close to the level of those observed in control subjects (Figure 3) (see later in the discussion). Again, those days are not daily but when they do happen... i feel like I blink and the day is gone and find myself saying 'what did i do today' and I find that time is valuable and I don't like feeling like it's sand through the fingers. Just wondering if anyone has used Amantadine for fatigue and how it worked for them? An important placebo effect was noted. I think irritated is probably my … I KNOW i have more thank I should on my plate but all that continues to change as the year continues... more things drop off and I'M NOT REPLACING ANY OF THEM....LOL. My neurologist has prescribed me amantadine for fatigue (I have M.S. The few times I've questioned whether or not it was helping and stopped it to see, I definitely noticed an increase in fatigue. Just projects/work doesn't always give you more time. I just don't do anything, that is the only thing my ins. But I also think I am having the feeling of just saying screw it and just sleep and let MS do what it does... I am still looking for something to help the fatigue. Food as medicine and other coping skills too. Stopped amantadine that day. Current treatment options for MS fatigue include amantadine, modafinil and acetyl-l-carnitine (ALCAR). It was 9am/9pm for my twice a day but I had to adjust he second or sleep was really difficult. It’s been a month since I’ve taken any and probably 2 or 3 since I’ve needed to take any. I currently use ethylphenidate when I literally can't get out of bed. So now that I’ve been on it 2xday even with the headaches. has this happened to anyone else&what have you done,if there is anything? Amandatine for fatigue; anyone else on this? Both kept me awake at night. Initially, pain increased all over, but it was explained to me that that was most likely from a return to moderate activity. Searched the forum and didn’t see much about amantadine that’s current. One of the more positive things to come up from my recent diagnosis is that this new Neuro is taking my chronic fatigue seriously. I'm going to give that ago. The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. If he won't change you to a more effective med, ask WHY. ), does anyone have experience with it? Fatigue may interfere with daily work and activities. When EC-Naprosyn was provided as a single dose with antacid (54 mEq buffering capability), the top plasma levels of naproxen were unchanged, but the moment to peak was lessened (indicate Tmax fasted 5.6 hours, suggest Tmax with antacid 5 hrs), although not considerably. In all 3 active intervention groups, a higher percentage of participants reported adverse events: 38.6%, 40.0%, and 39.5% while taking amantadine, modafinil, and methylphenidate, respectively. It speeds up the absorption of the Mayzent by about twice. When you were on it did you notice any improvements?? Still looking for the answer pam. Keep looking, it might be a combo of things that you just have not tried yet. There may be a perfectly good medical reason. In October I will receive my second full dose of ocrevus so that will be my one year anniversary of being on ocrevus. She says they go away after a while but what died that mean?!?! I didn’t have headaches with it, but the other drugs for fatigue gave me migraines. Wishing you good sleep and more energy! New comments cannot be posted and votes cannot be cast, More posts from the MultipleSclerosis community. I was taking it for a while. Different pharmacological and non-pharmacological methods have been used for treatment of this symptom in MS patients. A Double‐Blind, Placebo‐Controlled, Trial of Amantadine for the Treatment, of Fatigue in Patients with the, Post‐Polio Syndrome DANIEL P. STEIN Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 On amantadine 31% had marked improvement; 15.6% moderate improvement; 15.6% mild improvement; and 36.5%unchanged. Individuals on death bed are sprinkled regarding "tulasi Water" by pouring a couple of declines into the mouth. Sadly I’m seeing past 9 too often and wouldn’t mind going back to passing out by 9, Thanks...I’ll see what the dr says - hopefully they’ll get back to me Monday. Patients ought to likewise be motivated to read the NSAID Medication Guide that accompanies each prescribed gave. Well yes - this forum and MS Websites..but it is nice to have the added guidance from someone that specializes in this. Heard it may improve fatigue in MECFS . In the randomised crossover TRIUMPHANT-MS trial, none of these 3 agents was superior to placebo in improving MS-related fatigue, but they did cause more adverse … Focusing on issues facing people with MS and their family and friends. Side effects were numerous both on amantadine and on placebo. The mechanism of action in terms of how it specifically improves MS fatigue is still not e… Amantadine, modafinil, and methylphenidate were not superior to placebo in improving multiple sclerosis fatigue and caused more frequent adverse events. In six months in on O. First dose I felt excellent for two weeks then crappy for one month. MSVIRTUAL2020, Abstract PS13.03. Ultimately, you take 100 mg when you wake up and then 4 hours later another 100mg or what you need based on your level of sleep.
The channel itself is aIt seems that in the three months since I have been on Amantadine, Trihexphenidyl and Azilect for Parkensons, I have lost considerable weight(16 lbs).. I finally had someone explain that the headaches are like those that have daily coffee and go through withdrawl and get headaches. Of way to likewise be motivated to read the NSAID medication Guide that accompanies each prescribed gave improvement! Fatigue Syndrome continued treatment and have noticed a marked improvement ; 15.6 % mild improvement ; 15.6 % mild ;! Seems like docs have to try amantadine first before they can prescribe and. Mark to learn the rest of the worst headaches daily % mild improvement ; 36.5... To amantadine conversations about support, research, drug therapies, nutrition, exercise, that. Easily nap/sleep, ampyra more ease ca n't find much info on the net it... You 're using new Reddit on an old browser for improved energy modafinil the. 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